[Nieuws ENG] protein modelled on the body's own defences

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[Nieuws ENG] protein modelled on the body's own defences

Berichtdoor Lavender » vr feb 08, 2013 2:01 pm

'Natural' drug could offer long-lasting arthritis relief by 'rebooting' immune system

A single dose of a new drug could ‘reboot’ the immune system of patients with rheumatoid arthritis, say researchers.
They have developed a protein agent modelled on the body’s own natural defences to combat the inflammation that can destroy joints.
Rheumatoid arthritis affects around 400,000 adults, causing joint pain and swelling, stiffness, fatigue, and disability. At least 1,000 Britons a year have to give up work because of the condition.
Researchers from King’s College London and clinicians from Guy’s and St Thomas’ NHS Foundation Trust, London, are to start the first human trial of BiP – binding immunoglobulin protein – involving up to 50 patients.
The protein is part of the body’s normal anti-inflammatory response, but it is found in insufficient quantities in the joints of people with rheumatoid arthritis to have a therapeutic effect.
Previous work by the team indicates that giving an intravenous dose will quickly boost a patient’s anti-inflammatory response.
A single infusion appears to ‘reset’ their immune system and may give a long lasting effect.
Gabriel Panayi, professor emeritus of rheumatology at King’s College London, and honorary consultant rheumatologist at Guy’s and St Thomas, said: ‘If BiP works as we expect then a single dose should be sufficient to put patients into remission for months.
‘The most important thing is that our patients will have a better quality of life for longer. As a bonus, they should need fewer appointments which will free up valuable healthcare resources.’

Each year approximately 800,000 appointments are needed for existing patients, and about 80,000 for new patients.
Dr Valerie Corrigall of King’s College London said: ‘This trial is the culmination of 15 years of work – it’s very exciting to be at this stage.
‘Using patients’ own immune system to help protect against the disease is a new approach to treatment for rheumatoid arthritis.
‘As well as being a very promising therapy, we’ve purposefully designed BiP to be more cost effective than biologic therapies which work well but are extremely expensive.’

Professor Alan Silman, medical director of Arthritis Research UK charity, which is funding the two-year trial, said: ‘We’re very excited that the culmination of several years of support has resulted in a potential new treatment for rheumatoid arthritis.
‘This work is an example of where research funded by Arthritis Research UK has been translated into a possible new treatment that could come into clinical care within a reasonable time frame.’
Although rheumatoid arthritis is more common in older people it also affects many people of working age.’

Read more: http://www.dailymail.co.uk/health/artic ... z2KJA2p6qC
If you don’t like something, change it. If you can’t change it, change your attitude.
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Re: [Nieuws ENG] protein modelled on the body's own defences

Berichtdoor Lavender » vr feb 08, 2013 2:02 pm

Dat zou toch echt geweldig zijn niet? :D
If you don’t like something, change it. If you can’t change it, change your attitude.
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Re: [Nieuws ENG] protein modelled on the body's own defences

Berichtdoor Hermione » vr feb 08, 2013 2:12 pm

Zo, echt wel!!

Ik had hierover al gelezen, dat dit getest was op ratten. Maar nu dus al in het stadium van 'testen op mensen'... dat ze er maar gauw de Noordzee mee oversteken, en dat hier ook uit gaan testen! :)
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Re: [Nieuws ENG] protein modelled on the body's own defences

Berichtdoor Henk » za feb 09, 2013 4:12 am

Alhoewel ik de laatste zin van dit artikeltje in de Daily Mail... uh... wat 'vreemd' vind overkomen, zou dit een belangrijke aanwinst kunnen zijn bij het zo leefbaar mogelijk maken/houden van het leven van RA-patiënten en daarbij ook nog kostenbestrijdend zijn, "within a reasonable time frame".

Of en in hoeverre er sprake is van een doorbraak... fingers crossed (if possible)! :ewink:
'Tous les hommes sont mortels' ('Alle mensen zijn sterfelijk') van Simone de Beauvoir. Gelukkig wel!
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Re: [Nieuws ENG] protein modelled on the body's own defences

Berichtdoor Lavender » za feb 09, 2013 2:02 pm

Nu ja, ze beginnen nu dan met de eerste menselijke onderzoeken, dus ik denk dat het nog wel 10 jaar gaat zijn voor wij er gebruiken van zouden kunnen maken, áls het inderdaad werkt.
Maar het idee staat mij wel aan in ieder geval!
If you don’t like something, change it. If you can’t change it, change your attitude.
- Maya Angelou
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